Vikrant Singh Rajput

TB and anti-microbial therapeutics discovery and development.
Policy resaerch on bio-safety, bio-containment and bio-security.
Combating bacterial resistance using small molecules.
Exploring novel drug targets against bacterial pathogens.
Computational biology tools for drug discovery and vaccine design.
AI for TB detection.

Academic Qualifications

2017 Ph.D (Biological Science), Indian Institute of Integrative Medicine (CSIR), Jammu (J&K), India.

2010 B. Tech (Biotechnology), Amity University, Noida (UP), India.

Professional Experience

Dec, 2022-till date Assistant Professor, Department of Biomedical Engineering Central University of Rajasthan, Ajmer (RJ), India.

Mar, 2022-Nov, 2022 Scientist, Foundation for Neglected Diseases Research (FNDR), Bengaluru, (KA), India.

Jan, 2019-Jan, 2022 Young Scientist, School of Biotechnology, Jawaharlal Nehru University (JNU) Delhi,India.

Feb, 2018-Jan, 2019 Scientist, Bio-safety Support Unit, Regional Centre for Biotechnology (RCB), Lodhi Road, Delhi, India.

June, 2017-Feb, 2018 MHRD Postdoctoral Fellow, Indian Institute of Technology (IIT) Roorkee (UK), India.

July, 2016-May, 2017 Adhoc Faculty, National Institute of Technology (NIT), Raipur (CG), India.

Awards, Fellowships and recognitions

2024	India Biosecurity Fellowship, funded by United States (US) Department of state Bio-security Engagement Program (BEP).
2023	Young Scientist Award for a research talk at SABINP-2023, KL University (A.P).
2022	EMBO travel grant to present poster at NACARB-2022, Ascona, Switzerland.
2019	Young Scientist Fellowship and research grant award by Dept. of Health and Research (DHR), Govt. of India (Research grant worth Rupees Forty Six Lakhs for 3 years).
2017	MHRD Postdoctoral Fellowship, by Indian Institute of Technology (IIT), Roorkee.
2016	Poster Prize on World TB day symposium organized by AIIMS Delhi.
2015	Best Patent Award by CSIR-Indian Institute of Integrative Medicine (IIIM), Jammu (Govt. of India).
2013	Award for “Significant contribution in Discovery Biology for novel scaffolds in Tuberculosis” by CSIR-IIIM (Govt. of India)
2010	Qualified the country-wide research fellowship exam GATE conducted by IIT’s and IISc for Junior Research Fellowship (JRF) awarded by CSIR to pursue doctoral studies.

My research interests majorly include novel anti-TB and antimicrobial scaffold discovery, elucidating mechanism of action of whole cell active molecules, exploring novel drug targets and combating drug resistance using small molecules. Over the years, I have developed expertise in High Throughput Screening (HTS) against enzymes as well as susceptible and drug resistant whole cell organisms (M. tb in particular), major drug discovery assays ranging from screening to in depth characterization of lead molecules, bio-assay standardizations and molecular biology work.

I am also interested in working on and developing technologies defining PK/PD profile of anti-bacterial drugs for making right selections for clinical trials, exploring new antigens for developing cost effective point of care TB diagnostics and innovatory biomedical technologies/applications improving upon existing healthcare systems against microbial pathogens.

Motivated research oriented candidates (B. Tech./M. Tech./Msc.) interested in intenships are welcome to contact during office hours.

Candidates interested to pursue postdoctoral reserach having their OWN fellowship or willing to apply for a postdoctoral fellowship (NPDF, Dr. D S KOTHARI etc) tenable at Universities with overlapping reserach interests are welcome to contact through email.

S. No.	Authors	Title of Article	Journal/Conference Details	Journal/Conference	Publication Year
1	Vikrant Singh Rajput, Ashish Runthala and Inshad Ali Khan (*Corresponding Author)	Shikimate kinase inhibitors: An update on promising strategy against Mycobacterium tuberculosis	Current Drug Targets	Journal	2023

Journal Publications

Si no.	Author(s)	Title	Name of Journal	Volume	Page	Year
1	Harisomayajula Valli, Devi Prasanna, Vikrant Singh Rajput^,Wuriti Sridhar, N.N.V. Sakuntala, Padamata Harshavardhan and Ashish Runthala^^(*Corresponding Author)	Cis elements: Added Boost to the Directed Evolution of Plant Genes. https://doi.org/10.22207/JPAM.16.1.68	Journal of Pure and Applied Microbiology	16 (1)	663-668	2022
2	Vibha Shukla, Ashish Runthala, Vikrant Singh Rajput, Anurag tripathi, Suresh Phullara	Computational and synthetic biology approaches for the biosynthesis of antiviral and anticancer terpenoids from Bacillus subtilis doi: 10.2174/1573406417666210712211557	Medicinal Chemistry	18(3)	307-332	2022
3	Fatima Naaz, Arif Khan, Anchala Kumari, Intzar Ali, Faiz Ahmad, Bilal Ahmad Lone, Nazia Ahmad, Inshad Ali Khan, Vikrant Singh Rajput^* (corresponding Author), Abhinav Grover^, Syed Shafi^ ^*:Corresonding Author	1,3,4-oxadiazole conjugates of capsaicin as potent NorA efflux pump inhibitors of Staphylococcus aureus. https://doi.org/10.1016/j.bioorg.2021.105031	Bioorganic Chemistry	113(2019)	105031	2021
4	Rahul Sharma^#, Vikrant Singh Rajput^#, Salma Jamal, Abhinav Grover and Sonam Grover (#Authors contributed equally).	An Immunoinformatics approach to design a multi-epitope vaccine against Mycobacterium tuberculosis exploiting secreted exosome proteins. Doi: https://doi.org/10.1038/s41598-021-93266-w	Nature Scientific Reports	11	13836	2021
5	Vikrant Singh Rajput, Ritika Sharma, Anchala Kumari^,Nidhi Vyas,Vijay Prajapati and Abhinav Grover	Engineering a Multi Epitope Vaccine Against SARS-CoV-2 By Exploiting Its Non Structural and Structural Proteins Doi: https://doi.org/10.1080/07391102.2021.1924265.	Journal of Biomolecular and Structural Dynamics	26	1-18	May, 2021
6.	Anchala Kumari^,#, Vikrant Singh Rajput^#, Priya Nagpal, Himanshi Kukrety, Sonam Grover and Abhinav Grover. (#Authors contributed equally).	Dual inhibition of SARS-CoV-2 Spike and Main Protease through a repurposed drug, Rutin. https://doi.org/10.1080/07391102.2020.1864476	Journal of Biomolecular and Structural Dynamics	27	1-13	2020
7.	Ashish Runthala, Tavakala Harsha Sai , Vandana Kamjula , Suresh C Phulara , Vikrant Singh Rajput , Karthikeyan Sangapillai	Excavating the functionally crucial active-site residues of the DXS protein of Bacillus subtilis by exploring its closest homologues. doi: 10.1186/s43141-020-00087-x.	Journal of Genetic Engineering and Biotechnology	18	76	2020
8.	Vibha Shukla,, Somya Asthana, Sarika Yadava, Vikrant Singh Rajput, Anurag Tripathi	Emodin inhibited NADPH-quinone reductase competitively and induced cytotoxicity in rat primary hepatocytes https://doi.org/10.1016/j.toxicon.2020.10.018	Toxicon	188	117-121	2020
9.	Rukmankesh Mehra^#, Vikrant S. Rajput^# ,Monica Gupta, Reena Chib, Priya Wazir. Amit Kumar, Inshad A. Khan and Amit Nargotra (#Authors contributed equally).	Benzothiazole derivative as a novel Mycobacterium tuberculosis shikimate kinase inhibitor: Identification and elucidation of its allosteric mode of inhibition . DOI: 10.1021/acs.jcim.6b00056.	ACS Journal of Chemical Information and Modelling	56	930-940	2016
10.	Vikrant S. Rajput, Rukmankesh Mehra, Sanjay Kumar, Amit Nargotra and Inshad A Khan	Screening of anti tubercular library identifies novel Shikimate kinase inhibitors of M. tuberculosis DOI 10.1007/s00253-015-7268-8	Applied Microbiology and Biotechnology	100	5415 -26	2016
11.	Deepak Sharma, Vikrant Singh Rajput, Shamsher Singh, Rashmi Sharma,Insha d A. Khan, Debaraj Mukherjee	Ligand free palladium catalyzed synthesis of 3-Aryl/heteroaryl-4-indolylmaleimide and its antimicrobial activity. Doi:10.1002/slct.201600253	Chemistry Select	1	1954 -58	2016
12.	Rashmi Sharma Chitra Rani, Rukmankesh Mehra, Amit Nargotra Reena Chib, Vikrant S. Rajput, Sunil Kumar, Samsher Singh, Parduman R. Sharma, Inshad A. Khan.	Identification and characterization of Novel small molecule inhibitors of the Acetyltransferase Activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucos amine-1-phosphate-acetyltransferase (GlmU). DOI: 10.1007/s00253-015-7123-y.	Applied Microbiology and Biotechnology	100	3071 -85	2016
13.	Kushalava Reddy Yempalla, Gurunadham Munagala, Samsher Singh, Asmita Magotra, Sunil Kumar, Vikrant Singh Rajput, Sonali S. Bharate, Manoj Tikoo, G. D. Singh, Inshad Ali Khan, Ram A. Vishwakarm a, and Parvinder Pal Singh	Nitrofuranyl methyl piperazines as new Anti-TB agents: Identification, Validation, Medicinal Chemistry and PK Studies. DOI: 10.1021/acsmedchemlett.5b00141.	ACS Medicinal Chemistry Letters	6(10)	1041 -46	2015
14.	G. Munagala, K. R. Yempalla, S. Singh, S.Sharma, N. P. Kalia, Vikrant Singh Rajput, S. Kumar, S. D. Sawant, I. A. Khan, R.	synthesis of new generation triazolyl and isoxazolyl containing 6-nitro-2,3- dihydroimidazooxazoles as anti-tb agents: in vitro, structure-activity relationship, pk and in vivo evaluation doi:10.1039/c5ob00054h.	Organic Biomolecular Chemistry	13	3610-24	2015
15.	Syed Shafi, Fauzia Mir, M. S. Zaman, Nitin Pal Kalia, Vikrant Singh Rajput,Chaitanya Mulakayala, Naveen Mulakayala, Inshad A. Khan, M. S. Alam	Sulfur rich 2-mercapto benzothiazole and 1,2,3-triazole conjugates as novel antitubercular agents doi:10.1016/j.ejmech.2014.02.017.	European Journal of Medicinal Chemistry.	76	274-83	2014
16.	Gurunadham Munagala, Kushalava Reddy Yempalla, Sravan Kumar Aithagani, Nitin Pal Kalia, Furqan Ali, Intzar Ali, Vikrant Singh Rajput, Chitra Rani, Reena Chib, Rukmankesh Mehra, Amit Nargotra, Inshad Ali Khan,Ram A. Vishwakarma, Parvinder Pal Singh.	Synthesis 1 and biological evaluation of substituted N-alkylphenyl-3,5-dinitrobenzamide analogs as anti-TB agents DOI: 10.1039/c3md00366c.	Medicinal Chemistry Communication.	5	521-527	2014
17.	Narva Suresh , Hunsur Nagendra Nagesh , Janupally Renuka, Vikrant Rajput, Rashmi Sharma , Inshad Ali Khan , Chandra Sekhar Kondapalli Venkat	Synthesis and evaluation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4 (2-(4 substitutedpiperazin-1-yl)acetyl)piperazin-1-yl) quinoline-3-carboxylic derivatives as anti-tubercular and antibacterial agents https://doi.org/10.1016/j.ejmech.2013.10.055.	European Journal of Medicinal Chemistry.	71	324-32	2013
18.	. Mahapatra, N. Chauhan,D. R. Patel, N. P. Kalia, Vikrant Singh Rajput and I. A. Khan	Synthesis and antitubercular activity of oleanolic acid analogues https://doi.org/10.1007/s11094-014-1042-6.	Pharmaceutical Chemistry Journal	48	39-43	2013
19.	Anita Mahapatra, Vijay Maheswari, Nitin Pal Kalia, Vikrant S Rajput, Inshad Ali Khan	Synthesis and antitubercular activity of berberine derivatives https://doi.org/10.1007/s10600-014-0942-8	Chemistry of natural compounds	50	321–325	2014
20.	Ahmed Kamal, Syed Mohammed Ali Hussaini, Shaikh Faazil, Y. Poornachandra, G. Narender Reddy ,C. Ganesh Kumar,Vikrant Singh Rajput , Chitra Rani , Rashmi Sharma, Inshad Ali Khan, N. Jagadeesh Bab	Anti-tubercular agents. part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3- triazoles DOI:0.1016/j.bmcl.2013.10.010.	Bioorganic and medicinal chemistry letters.	23	6842-6	2013
21.	Jean P. Dzoyem, Antoine H. L. NKuete, Victor Kuete, Michel F. Tala, Hippolyte K. Wabo, Santosh K. Guru, Vikrant Singh Rajput, Akash Sharma, Pierre Tane, Inshad A. Khan, Anil K. Saxena, Hartmut Laatsch, Ning-Hua Tan	Cytotoxicity and antimicrobial activity of the methanol extract and compounds from polygonum limbatum. DOI: http://dx.doi.org/ 10.1055/s-0031-1298431.	Planta Medica	78	787-92	2012
22.	Chandrasekar Balachandran, Veeramuthun Michael Karunai Raj, Savarimuthu Ignacimuthu, Kedike Balakrishna, Vikrant Singh Rajput, Nitin Pal Kalia, Inshad Ali Khan	Antimycobacterial and cytotoxic (a549) properties of vasicinone isolated from adhatodavasica (l.) nees DOI: 10.1186/1472-6882-12-242	Asian Pacific Journal of Tropical Biomedicine.	1	1 to 4	2012
23.	. Naif Abdullah Al-Dhabi, Chandrasekar Balachandran, Michael Karunai Raj, Veeramuthu Duraipandiyan, Chinnasamy Muthukumar, Savarimuthu Ignacimuthu, Inshad Ali Khan and Vikrant Singh Rajput	Antimicrobial, antimycobacterial and antibiofilm properties of couroupita guianensis aubl. fruit extract DOI: https://doi.org/10.1186/1472-6882-12-242.	BMC Complementary and Alternative Medicine.	12	242	2012
24	Chandrasekhar Balachandran, Veeramuthu Duraipandiyan ,Naif Abdullah Al-Dhabi , K. Balakrishna, Nitin Pal Kalia, Vikrant Singh Rajput, Inshad Ali Khan, Savarimuthu Ignacimuthu	Antimicrobial and Antimycobacterial Activities of Methyl Caffeate Isolated from Solanumtorvum Swartz. Fruit	Indian Journal of Microbiology.	52	676-81	2012

Patents

Singh, P. P.; Munagala, G.; Kushalava,R.Y.; Khan,I. A.; Kalia, N. P.; Singh ,V. R.; Nargotra, A.; Sawant,S. D.; Vishwakarma,Ram Aarey. 6-Nitro-2,3-dihydroimidazo[2,1-b] oxazoles and a process for the preparation thereof.

S. no.	Country/Organization	Legal Staus	Patent No.
1.	India	ACTIVE Filling Date: 2013-10-04 Anticipated expiration: 2034-03-31	IN2954DE2013A
2.	European Union		EP3052503A1
3.	European Union		EP3052503B1
4.	Spain		ES2707362T3
5.	Japan		JP2016531898A
6.	Japan		JP6532457B2
7.	Taiwan		TW201514184A
8	Taiwan		TWI654192B
9.	USA		US2016244462A1
10.	USA		US9845330B2
11.	WIPO		WO2015049693A

Chapters Contributed in Books

Chitra Rani*, Vikrant Singh Rajput, Shah Ubaid-ullah* (2023).. Structural biology an essential tool for Drug discovery and Development. A chapter in "Drugs and a Methodological Compendium" (Springer).
Suresh Chandra Phulara, Nazia Ahmad, Bidyut Mazumdar and Vikrant Singh Rajput* (2019). Microbiological advances in bioactives from high altitude. A chapter in "Microbiological Advancements For Higher Altitude Agro-Ecosystems and Sustainability” (Springer). (*Corresponding Author)
Suresh Chandra Phulara, Vikrant Singh Rajput, Bidyut Mazumdar and Ashish Runthala (2019). Terpenoids: An anticancer therapeutics perspectives. A chapter in “Essentials of cancer genomic, computational approaches and precision medicine” (Springer).
Naif Abdullah Al-Dhabi, Chandrasekar Balachandran, Michael Karunai Raj,Veeramuthu Duraipandiyan, Chinnasamy Muthukumar, Savarimuthu Ignacimuthu, Inshad Ali Khan, and Vikrant Singh Rajput (2014). Antimicrobial, Antimycobacterial and Antibiofilm Properties of Couroupita guianensis Aubl. Fruit Extract. A chapter in the book “Biofilm Control and Antimicrobial Agents” (Apple Academic Press, New Jersey, USA ) Editors: S.M. Abu Sayem Pub Date: March 5, 2014, ISBN: 9781771880022.

Books edited

Drugs and a Methodological Compendium (2023) (Springer) ISBN-13:978-9811979514, Ed. Vikrant Singh Rajput & Ashish Runthala.

Title

Funding Agency

Role

Amount

Duration

Year of Sanction

Exploring the enoyl CoA hydratase as potential antitubercular drug target.

Dept. of Health Research

(Govt. of India)

PI

46 Lakhs

3 years

2019

Attended

Workshop

1.Biosecurity Workshop held from 04/09/2024-06/09/2024 funded by United States (US) Department of state Bio-security Engagement Program (BEP) at Sunway Manor, Pondicherry.

2. One Week FDP (01-07/07/2023) on blended learning concepts and tools from Teaching Learning Centre Ramanujan College, University of Delhi.

3. One Week FDP (29/05/2023-04/06/2023) on NEP-2020 from Teaching Learning Centre Ramanujan College, University of Delhi.

4. Four (4) Week Faculty Induction/Orientation Programme (20/01/2023-18/02/2023) for faculty in Universities/Colleges/Institutes of Higher Education completed with A+ Grade from Teaching Learning Centre Ramanujan College, University of Delhi.4. 5. Short term course on

5. Workshop on "Computational structure based drug design, Biologics design and Molecular dynamics" held from Dec. 14^th-18^th,2019 organized by Dept. of Biotechnology National Institute of Technology, Raipur with Schrodinger Inc. Bengaluru, India.

6. Biorisk Management Workshop conducted by Sandia National Laboratories, USA on 25, Aug 2014 at IIIM, Jammu.

Poster Presentation

1. Presented poster titled “Screening and identification of inhibitors of Shikimate kinase of M. tuberculosis from whole cell active library” in the international conference on Drugs for the Future: Infectious Diseases- 2014, Antimicrobial Drug Discovery: Challenges and Perspectives at NIPER, Hyderabad.

2. Presented poster titled “Identification of an allosteric inhibitor of Mycobacterium tuberculosis Shikimate kinase” at world TB day Symposium "Challenges in tuberculosis diagnosis and treatment", on 30th March, 2016 at, All India Institute of Medical Sciences (AIIMS), New Delhi.

Invited Lecture/Oral presentation

1. Oral presentation/research talk at "International Conference on Current Sustainable Agricultural, Biotechnological, Nutritional and Pharmaceutical Interventions to Combat Global Challenges"-Dec. 2023 at KL University, Vijayawada. Abstract title: “Capsaicin analogues as potent antibiotic potentiator against Staphylococcus aureus”

2. Undertook invited academic lectures at K.L University Guntur, A.P in 2020 and 2021.

Title	Attachment File	Other Link
	Vikrant S. Rajput CURAJ CV 2023 (1).pdf	https://scholar.google.co.in/citations?hl=en&user=5ybfP0EAAAAJ

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Dr. Vikrant Singh Rajput

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